NESI is a partnership between the University of Antwerp and the public and private sector. An Executive Secretariat coordinates and implements activities for the network. The Executive Secretariat is based at the Department of Epidemiology and Social Medicine, University of Antwerp, Belgium.
The Executive Secretariat reports to the Oversight Committee, which advises on strategy and funding opportunities, and reviews outcomes. The Oversight Committee is composed of representatives from this partnership, representatives of partner universities and international health organisations and alliances, and international vaccinology experts.
NESI has full operational and scientific independence.